Ingredients: Turmeric (Curcuma longa), Cinnamon (Cinnamomum spp.), Ginger (Zingiber officinale), Cayenne Pepper (Capsicum annuum), Black Pepper (Piper nigrum)
Who It’s For
Spice Combo 5-in-1 Capsules are designed for adults who want a daily, food-like tonic to support digestion, metabolism, circulation, and overall vitality, using time-honoured kitchen spices. It is suited for individuals who experience sluggish digestion, bloating after meals, cold hands and feet, mild blood sugar fluctuations, low energy, or inflammatory discomfort, and prefer a gentle, culinary-style herbal approach rather than harsh stimulants or single-target drugs. Spice Combo 5-in-1 is designed to be used in conjunction with a whole-food diet, regular physical activity, stress management, and appropriate medical care for any diagnosed metabolic or inflammatory condition.
Health Benefits Summary
Spice Combo 5-in-1 is formulated as a warming, circulation-enhancing, and digestion-supportive daily blend of turmeric, cinnamon, ginger, cayenne, and black pepper. Together, these spices offer a rich array of polyphenols and bioactive compounds that may help modulate inflammation, support healthy blood sugar regulation, enhance digestive comfort and nutrient absorption, and gently stimulate circulation and metabolic activity. Turmeric exhibits well-studied anti-inflammatory properties; cinnamon supports glucose control; ginger soothes and stimulates the digestive tract; cayenne promotes thermogenesis and blood flow; and black pepper enhances the bioavailability of various compounds. Used regularly with healthy lifestyle changes, Spice Combo 5-in-1 aims to support overall well-being, natural defences, and internal balance.
Detailed Health Benefits
• Digestive Comfort, Bloating & Motility
How it Helps: Supports more comfortable digestion, helping to ease feelings of fullness, bloating, and “heaviness” after meals, while gently promoting gastric motility.
How it Works: Ginger has long been used as a carminative and pro-digestive spice. Clinical studies and recent reviews report that ginger supplementation can reduce symptoms of functional dyspepsia—such as bloating, early fullness, and upper abdominal discomfort—when compared with a placebo, supporting its role in improving upper gastrointestinal comfort. (3)
• Blood Sugar Balance & Metabolic Support
How it Helps: Supports healthy glycaemic control and insulin function when combined with a low-glycaemic, nutrient-dense eating pattern—essential for managing cravings, energy dips, and long-term metabolic health.
How it Works: Cinnamon appears to mimic and enhance aspects of insulin action, improving glucose uptake in tissues. A systematic review and meta-analysis in people with type 2 diabetes found that cinnamon supplementation significantly improved glycaemic control measures (including HbA1c and fasting plasma glucose), suggesting value as an adjunct to standard diet and lifestyle measures. (2)
• Inflammation Modulation & Antioxidant Defence
How it Helps: Provides broad antioxidant and anti-inflammatory support that may help reduce low-grade inflammation and oxidative stress, both of which are essential contributors to chronic disease risk and feelings of stiffness or fatigue.
How it Works: Curcumin, the principal polyphenol in turmeric, has been extensively studied in human trials. A systematic review and meta-analysis of randomised controlled trials found that oral curcumin supplementation significantly reduced key inflammatory markers such as C-reactive protein (CRP) and specific cytokines in chronic inflammatory conditions, confirming its anti-inflammatory activity in clinical settings. (1)
• Circulation, Warmth & Thermogenesis
How it Helps: Supports peripheral circulation and promotes a gentle increase in metabolic activity, which may be experienced as improved warmth, increased energy, and enhanced support for weight-management efforts when combined with a balanced diet and regular exercise.
How it Works: Cayenne provides capsaicin, which activates TRPV1 receptors and can increase sympathetic activity, energy expenditure, and fat oxidation. A systematic review and meta-analysis of capsaicin intake in overweight and obese adults found modest reductions in BMI, body weight and waist circumference, indicating a small but measurable thermogenic and metabolic effect. (4)
• Nutrient Absorption & Formula Synergy
How it Helps: Supports the absorption and bioavailability of co-ingested nutrients and phytochemicals, allowing you to derive greater benefits from both this blend and other foods or supplements taken in conjunction with it.
How it Works: Black pepper contains piperine, a well-known bioavailability enhancer. Classic pharmacology work demonstrated that piperine inhibits several hepatic drug-metabolising enzymes and can markedly increase the bioavailability of various compounds, providing a mechanistic basis for its traditional use in spice combinations and herbal formulas to “potentiate” effects. (5)
Key Ingredients – Evidence-Based Actions
• Turmeric (Curcuma longa) – Anti-Inflammatory & Antioxidant Spice
How it Helps: Supports healthy inflammatory responses, joint comfort, and overall antioxidant status, contributing to long-term metabolic and cardiovascular health.
How it Works: Curcumin, the principal polyphenol in turmeric, modulates multiple inflammatory pathways (e.g. NF-κB, COX-2, cytokines) and acts as an antioxidant. A systematic review and meta-analysis of RCTs on oral curcumin in chronic inflammatory diseases found significant reductions in CRP and other inflammatory markers compared with placebo, supporting its anti-inflammatory effect in humans.(1)
Research:
– Anti-inflammatory effects of oral supplementation with curcumin: a systematic review and meta-analysis of randomized controlled trials
• Cinnamon (Cinnamomum spp.) – Glycaemic & Metabolic Support
How it Helps: Helps support healthy blood-sugar control, insulin sensitivity, and aspects of metabolic health, particularly as an adjunct in individuals with elevated glucose when combined with diet and movement.
How it Works: Cinnamon appears to enhance insulin-receptor signalling and glucose uptake into cells. A systematic review and meta-analysis of type 2 diabetes reported beneficial effects of cinnamon on HbA1c and fasting plasma glucose, indicating improved glycaemic control.(2)
Research:
– Cinnamon in glycaemic control: systematic review and meta-analysis
• Ginger (Zingiber officinale) – Digestive Comfort & Gut Motility
How it Helps: Traditionally used to relieve nausea, bloating, and digestive discomfort, and to promote more comfortable post-meal digestion.
How it Works: Gingerols and shogaols influence gastric motility and visceral sensitivity. A recent review and pooled analysis of clinical trials concluded that ginger supplementation can improve at least some dyspepsia symptoms, such as bloating, fullness, and abdominal pain—in functional gastrointestinal disorders, supporting its role as a carminative and GI-soothing spice. (3)
Research:
– The effects of ginger supplementation on common gastrointestinal symptoms: a systematic review of clinical trials
• Cayenne Pepper (Capsicum annuum) – Capsaicin, Circulation & Thermogenesis
How it Helps: Provides a warming, circulation-enhancing “kick” that may modestly increase energy expenditure and support weight-management efforts when combined with diet and exercise.
How it Works: Capsaicin activates TRPV1 channels in sensory neurons, increasing sympathetic nervous system activity and promoting thermogenesis and fat oxidation. A 2023 systematic review and meta-analysis of capsaicin intake in overweight and obese adults found modest but significant reductions in BMI, body weight, and waist circumference compared with control, indicating minor supportive effects on weight-related measures. (4)
Research:
– The effects of capsaicin intake on weight loss among overweight and obese subjects: a systematic review and meta-analysis of randomized controlled trials
• Black Pepper (Piper nigrum) – Piperine & Bioavailability Enhancement
How it Helps: Enhances absorption and systemic availability of various nutrients and phytochemicals, supporting the overall effectiveness of the spice blend and co-supplemented compounds.
How it Works: Piperine inhibits several hepatic and intestinal drug-metabolising enzymes and efflux pumps. Classic work in animal models showed that piperine significantly inhibited multiple biotransformation reactions in rat hepatic tissue, providing the biochemical basis for its capacity to enhance bioavailability. (5)
Research:
– Biochemical basis of enhanced drug bioavailability by piperine: evidence that piperine is a potent inhibitor of drug metabolism
Dosage Guidelines
• Prevention (Daily Spice Tonic & Wellness Support) — 1 capsule once daily with food.
For adults seeking gentle, daily support for digestion, circulation, and metabolic balance as part of a generally healthy lifestyle.
• Maintenance (Digestive & Metabolic Support) — 1 capsule twice daily with main meals.
For individuals working on digestive comfort, mild blood-sugar fluctuations, or inflammatory/metabolic wellness who need ongoing support alongside diet and exercise.
• Therapeutic (Short-Term Intensive Support) — 2 capsules twice daily with meals.
For brief periods of increased need (e.g., heavier meals, times of inflammatory flare or metabolic strain) under guidance from a healthcare professional. Once symptoms and overall well-being improve, reduce to Maintenance or Prevention levels.
Tips for Best Results:
Take Spice Combo 5-in-1 Capsules with food, especially main meals, to support digestive comfort and optimal absorption of fat-soluble constituents. Combine use with a whole-food, plant-rich diet, adequate fibre, and healthy fats (e.g., olive oil, avocado, nuts), as many spice polyphenols work synergistically with dietary lipids. Limit ultra-processed foods, refined sugars, and excessive alcohol, which can cause inflammation and metabolic stress. Regular movement, good sleep, stress-management practices, and avoiding smoking all strongly influence how effectively this spice blend can support your health. For most metabolic and inflammatory benefits, allow at least 6–12 weeks of consistent use alongside lifestyle changes before assessing full effects.
Warnings & Interactions
• General:
– Adults only. Not recommended during pregnancy or breastfeeding unless advised by a qualified healthcare professional.
– Not a substitute for prescribed treatment of diabetes, cardiovascular disease, inflammatory arthritis, or other chronic conditions.
• Digestive Sensitivity (Turmeric, Ginger, Cayenne):
– These spices can cause gastrointestinal upset (heartburn, abdominal discomfort, loose stools) in some individuals, especially at higher doses.
– Use cautiously in people with active peptic ulcer disease, severe reflux, gastritis, or inflammatory bowel disease; discontinue if symptoms worsen.
• Gallbladder & Bile Duct Issues (Turmeric):
– Turmeric/curcumin may stimulate bile flow; avoid in known gallstones, biliary obstruction, or acute gallbladder disease unless supervised.
• Blood-Sugar-Lowering Medicines (Cinnamon):
– Cinnamon may modestly reduce blood-sugar levels. Use cautiously with insulin or oral hypoglycaemics; monitor glucose regularly and adjust medications only with professional guidance.
• Bleeding Risk (Turmeric, Ginger, Cayenne):
– These spices may have mild antiplatelet effects. Use cautiously with anticoagulant or antiplatelet medications (e.g., warfarin, DOACs, aspirin, clopidogrel) or in patients with bleeding disorders. Stop use before major surgery, as advised by a healthcare professional.
• Black Pepper / Piperine – Drug Metabolism:
– Piperine can inhibit drug-metabolising enzymes and may increase blood levels of certain medications.
– Use particular caution with medicines that have a narrow therapeutic index (e.g. some anti-epileptics, immunosuppressants, antiarrhythmics); consult the prescribing doctor before use.
• Allergies:
– Do not use if you are allergic to any listed spice or to the Zingiberaceae (ginger/turmeric) or Piperaceae / Lauraceae plant families.
• Drug Interactions (General):
– Individuals taking chronic prescription medicines for cardiovascular disease, diabetes, clotting disorders, epilepsy, autoimmune conditions, or organ transplantation should consult their healthcare provider before using this product.
• Stop use if any adverse reaction occurs. Keep out of reach of children.
⚠️ Disclaimer
Natural spice-based herbal supplement for general digestive, metabolic, circulatory and immune wellness support as part of a healthy lifestyle.
Not intended to diagnose, treat, cure, or prevent any disease.
Statements reflect traditional use and general wellness support and have not been evaluated by SAHPRA.
Consult a healthcare professional before use, especially if pregnant or breastfeeding, using chronic medication, have liver, kidney, gallbladder, gastrointestinal, cardiovascular, bleeding, metabolic, or autoimmune conditions, or any other underlying medical issues.
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